_Stefan Uroš II Milutin NEMANJIĆ _+
                                                        | (1253 - 1321)                      
                           _Stefan Uroš III NEMANJIĆ _|
                          | (1282 - 1331)               |
                          |                             |_Helena KOMNENOSDOUKAS _____________+
                          |                                                                  
 _Simeon Uroš NEMANJIĆ _|
| (1326 - 1370)           |
|                         |                              _John PALAIOLOGOS __________________+
|                         |                             | (1288 - 1326)                      
|                         |_Maria of PALAIOLOGOS _______|
|                           (.... - 1355)               |
|                                                       |_Irene METOCHITES __________________
|                                                                                            
|
|--Maria of NEMANJIĆ 
|  (1350 - 1394)
|                                                        _John I ORSINI _____________________+
|                                                       | (.... - 1317)                      
|                          _John II ORSINI _____________|
|                         | (.... - 1335)               |
|                         |                             |_Maria KOMNENOSDOUKAS ______________+
|                         |                                                                  
|_Thomais ORSINI _________|
  (1330 - ....)           |
                          |                              _Andronikos KOMNENOSDOUKAS _________+
                          |                             | (1282 - 1328)                      
                          |_Anna KOMNENOSDOUKAS ________|
                                                        |
                                                        |_Kokala of UNKNOWN _________________