_Claude LORRAINE ________________+
                                               | (1496 - 1550) m 1513            
                          _Francis II GUISE ___|
                         | (1518 - 1562) m 1548|
                         |                     |_Antoinette of BOURBON-VENDÔME _+
                         |                       (1494 - 1582) m 1513            
 _Henry I GUISE _________|
| (1550 - 1588) m 1570   |
|                        |                      _Ercole II ESTE _________________+
|                        |                     | (1508 - 1559)                   
|                        |_Anna of ESTE _______|
|                          (1531 - 1607) m 1548|
|                                              |_Renee of VALOIS-ORLÉANS _______+
|                                                (1510 - 1574)                   
|
|--Francois GUISE 
|  (1581 - 1582)
|                                               _________________________________
|                                              |                                 
|                         _____________________|
|                        |                     |
|                        |                     |_________________________________
|                        |                                                       
|_Catherine of LA MARCK _|
  (1548 - 1633) m 1570   |
                         |                      _________________________________
                         |                     |                                 
                         |_____________________|
                                               |
                                               |_________________________________